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Physicians should establish baseline levels of IGF-1, fasting insulin, HbA1c, and a comprehensive metabolic panel prior to initiation

The majority of the existing evidence is derived from preclinical animal models, with limited data available from human studies

Because the information provided was often limited and because these events can be influenced by other potential factors, the FDA determined that the information in these reports did not demonstrate a clear relationship with the use of GLP-1 RAs